New York, Nov 13 : A team of US researchers are conducting studies to understand whether botanical therapies like medicinal mushrooms and Chinese herbs provide therapeutic benefit in treating acute Covid-19 cases.New York, November 13, 2018 : .A group of US researchers is conducting research to determine if botanical therapies such as medicinal mushrooms or Chinese herbs can be used in acute Covid-19 cases.
According to principal investigator Gordon Saxe, director of research at the Center for Integrative Health in University of California-San Diego, mushrooms were chosen because of their long history of use and recent evidence of immune-enhancing and antiviral effects.Gordon Saxe (principal investigator, Center for Integrative Health, University of California-San Diego), director of research, said that mushrooms were selected because of their long-standing use and evidence of immune-enhancing or antiviral properties.
MACH-19 (Mushrooms and Chinese Herbs for Covid-19) is a multi-centre study led by UC San Diego’s School of Medicine and UC-Los Angeles, in collaboration with the La Jolla Institute for Immunology.MACH-19 (Mushrooms & Chinese Herbs for Covid-19), is a multicentre study that was led by UC San Diego’s School of Medicine, UC-Los Angeles and the La Jolla Institute for Immunology.
In a preclinical study published in 2019, mushroom agarikon was found to inhibit viruses, including influenza (H1N1), influenza A (H5N1) and herpes.
Preclinical studies published in 2019 showed that mushrooms agarikon inhibited viruses such as influenza A (H5N1), H1N1), and herpes.Saxe said he believes medicinal mushrooms inhibit the viruses’ replication, a theory he plans to test against SARS-CoV-2 in a Phase II trial.
Saxe stated that he believes medicinal mushrooms prevent viruses from reproducing, which he will test in Phase II.
“Mushrooms have the advantage that they co-evolved with us.”Mushrooms share the advantage of co-evolving with us.So bacteria, viruses and other fungi prey on mushrooms just like they prey on humans.The same bacteria, viruses, and other fungi that prey upon mushrooms as they do on humans also prey on them.And mushrooms have developed exquisite defenses against those pests, and we believe they can confer those to us when we eat them,” Saxe said.Saxe stated that mushrooms have amazing defenses against pests and they believe they can give those to us when eating them.”
MACH-19’s third ongoing trial measures whether the same medicinal mushrooms, given in capsules at the time of initial Covid vaccination, can increase antibodies and other measures of immune response.MACH-19’s third ongoing study examines whether identical medicinal mushrooms given in capsules during initial Covid vaccination can increase antibodies and other immune responses.
A fourth trial, yet to be launched, will look at whether medicinal mushrooms could provide a similar lift to Covid-19 booster shots as an adjuvant, a substance which enhances immune response.
The fourth trial will examine whether medicinal mushrooms can provide an adjuvant effect, which is a substance that enhances the immune response, similar to Covid-19 booster shots.
“Vaccines lead to the production of antibodies that can destroy the virus in the blood,” Saxe said.
Saxe stated that vaccines can lead to the production antibodies that can kill the virus in the blood.
“Mushrooms may not only increase the number of these antibodies, but also enhance T-cell immunity against virally infected cells.”Mushrooms not only increase the amount of these antibodies but also boost T-cell immunity to virally infected cells.Further, because mushrooms bind to receptors on human immune cells, they can modulate our immunity — boosting it in some ways and calming it down in others.
Because mushrooms bind to human immune cells’ receptors, they can modulate immunity in a variety of ways.They can boost it in certain ways while calming it down in other.
And this property of mushrooms may also reduce vaccine-related side effects.This property may reduce side effects of vaccines.
Natural therapeutics have been used for centuries to treat infectious diseases, according to Saxe, who noted that herbs helped Chinese doctors manage 300 recorded epidemics, while the Greek pharmacologist Pedanius Dioscorides prescribed agarikon to treat pulmonary infections 2,300 years ago.According to Saxe, natural therapeutics have been used for centuries in the treatment of infectious diseases.He noted that Chinese doctors managed 300 epidemics with herbs, while a Greek pharmacologist Pedanius dioscorides prescribed agarikon 2300 years ago to treat pulmonary infections.
The three trials, under MACH-19 of which two are Food and Drug Administration (FDA)-approved, are currently recruiting for between 66 and 80 patients who have tested positive for SARS-CoV-2 and who are quarantined at home with mild to moderate symptoms.
AInitial safety data from the trials are expected by the end of this year, with efficacy data ready within a year.Three trials under MACH-19, two of which are FDA-approved, currently recruit for patients with mild to moderate symptoms and who have tested positive #explore #Chinese #herbs #medicinal #mushrooms #treat
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