Hyderabad 12th of September : Human immune systems doesn’t create the defense molecules against the Delta variant as efficiently as it does against other varieties of coronavirus, as revealed in the results of a study.Dr.Krishnan Harshan’s team led the study in collaboration with Dr.Sowpati’s group at the CSIR-Centre for Cellular and Molecular Biology.to determine the way that hosts, which are people infected by the virus react differently to different variants of SARS-CoV-2.
In this study , which was published in Microbiology Spectrum journal, researchers found that the immune system did not produce the defense molecules to fight the Delta variant as efficiently as other variants.
While infection caused by other variants alerted the immune system swiftly but the Delta variant could be silently replicate in the cells of the host.
In the past three years there have been a variety of SARS-CoV-2 variants that have been circulating across the globe.
Their outcomes have varied widely, with the Delta variant being the most deadly.
The researchers identified five distinct SARS-CoV-2 variants and examined the way the human immune system reacts to these variants.
The variants that were studied were Alpha, Delta, and three additional variants that appeared prior to the Alpha variant.After infection by a virus the initial option of attack from the immune system of the host is by producing certain chemicals that help break down viruses.
Researchers studied the way that their production reacts to these five variations.
“We infected human cells in the cell culture system with these diverse varieties of the virus and then monitored the creation of known immune defense molecules as well as the activation of signaling pathways that are associated with these molecules,” said Dixit Tandel the lead author of the study.
“We have walked through the hundreds of immune pathways that are familiar to us by high-throughput analysis and sequencing,” said Dr.Nitesh Kumar Singh, who was involved in the project with Dr.Sowpati.
“We have discovered that molecular mechanisms controlling the immune response of the host are not as effective against the Delta variant of SARS-CoV-2.
This involves the creation of interferons which are immune-modulating molecules that are commonly used in antiviral treatments.The study provides insight into the reasons why the Delta variant may be more easily spread,” said Dr.Krishnan Harshan, the lead researcher in this study.
He added that the research will help us to understand how viruses change with changing impacts on humans.
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