Dehydration Preventing Hormone Linked To Worsening Kidney Disease: Study

The hormone that prevents dehydration is linked to a worsening of kidney disease: Research

New York, Aug 15 : A aldosterone, a steroid hormone -that is known to protect against dehydration by controlling water and salt in the body is associated with the likelihood of kidney failure in patients with chronic kidney disease (CKD) according to a study conducted by an Indian-American scientist.
Aldosterone is a steroid hormone produced by the adrenal glands that are located just above the kidneys.

 Dehydration Preventing Hormone Linked To Worsening Kidney Disease: Study-TeluguStop.com

It plays an important function in control of blood pressure.However, excessive amounts of it can result in high blood pressure and kidney disease, as well as cardiovascular.

The study, which was published in the European Heart Journal, showed that the possibility of CKD becoming worse and advancing into kidney failure at the end of its stage was independent of whether or not the patient had diabetes.

The team, headed by Dr Ashish Verma, Assistant Professor at the Boston University School of Medicine, US, investigated the connections between aldosterone concentrations in the blood and the progression of kidney disease among 3,680 individuals aged between 21 and 74 years old.

They were focusing on CKD progress which is defined as a 50%% decrease in the capacity of kidneys to remove blood from blood vessels in the glomerular artery, also known as the estimated glomerular filter rate (eGFR) or end-stage kidney disease whichever occurs first.After a follow-up of more than ten years, CKD progress was observed in 1,412 (38 percent) of the participants.

The study found that higher levels of aldosterone were related with lower eGFR and less concentrations of potassium in the blood, and higher levels of protein and potassium in urine.

Additionally, they discovered that each increase of aldosterone levels in blood samples was associated with an 11 percent increase in risk of CKD progress.

The patients with levels in the top 25 percent of the group had a 45 percent higher risk of developing the disease compared to 25% of those with the lowest levels of aldosterone.The risk was the same regardless of whether or not the patient have diabetes.

The results are significant as they indicate that aldosterone is involved in an important function in the progression of CKD as well as blood vessel and heart issues and that an existing drug that targets the actions of aldosterone could help stop CKD becoming worse.

The US Food and Drug Administration (FDA) has approved the use of finerenone in patients with CKD and diabetes.Finerenone targets the mineralocorticoid receptor (MR).In the event that this receptor gets activated by aldosterone high levels of the hormone cause high blood pressure kidney and cardiovascular diseases, Verma said.

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Disclaimer : TeluguStop.com Editorial Team not involved in creation of this article & holds no responsibility for its content..This Article is Provided by IANS, Please contact IANS if any issues in Article .


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